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Product Info Summary
| SKU: | A02287 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Noxa Pmaip1 Antibody
SKU/Catalog Number
A02287
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Noxa Pmaip1 Antibody (Catalog # A02287). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Noxa antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Noxa Pmaip1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02287)
Host
Rabbit
Contents
Noxa Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Noxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa. The immunogen is located within the first 50 amino acids of Noxa.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
IL-28B antibody is human specific. IL-28B antibody may cross-react with IL-28A and IL-29.
Reactive Species
A02287 is reactive to PMAIP1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
11566 MW
Background of Noxa
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02287 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Noxa antibody can be used for detection of Noxa by Western blot at at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 1 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5
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Immunohistochemistry of NOXA in human stomach tissue with NOXA antibody at 2.5 μg/ml.
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Immunofluorescence of Noxa in Human Stomach cells with Noxa antibody at 10 μg/mL.
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Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PMAIP1 (Source: Uniprot.org, NCBI)
Gene Name
PMAIP1
Full Name
Phorbol-12-myristate-13-acetate-induced protein 1
Weight
11566 MW
Superfamily
PMAIP1 family
Alternative Names
Noxa, Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 phorbol-12-myristate-13-acetate-induced protein 1|PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PMAIP1, check out the PMAIP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PMAIP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Noxa Pmaip1 Antibody (A02287)
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