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Product Info Summary
| SKU: | A04916 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-NK3R TACR3 Antibody
View all NK3R/TACR3/Neurokinin B Receptor Antibodies
SKU/Catalog Number
A04916
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NK3R TACR3 Antibody (Catalog # A04916). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
NK3R antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NK3R TACR3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04916)
Host
Rabbit
Contents
NK3R Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R. The immunogen is located within amino acids 370 - 420 of NK3R.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
NK3R antibody does not recognize NK1R or NK2R.
Reactive Species
A04916 is reactive to TACR3 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
52202 MW
Background of NK3R/TACR3/Neurokinin B Receptor
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04916 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NK3R antibody can be used for detection of NK3R by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NK3R in RAW264.7 cell lysate with NK3R antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of NK3R in human brain tissue with NK3R antibody at 5 μg/mL.
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Immunofluorescence of NK3R in Human Brain tissue with NK3R antibody at 20 ug/mL.
Protein Target Info & Infographic
Gene/Protein Information For TACR3 (Source: Uniprot.org, NCBI)
Gene Name
TACR3
Full Name
Neuromedin-K receptor
Weight
52202 MW
Superfamily
G-protein coupled receptor 1 family
Alternative Names
NKR, HH11, NK3R, NK-3R, TAC3RL, TAC3R, Neuromedin-K receptor, NK-3 receptor, NKR TACR3 HH11, NK-3R, NK3, NK3R, NKR, TAC3R, TAC3RL tachykinin receptor 3 neuromedin-K receptor|NK-3 receptor|NK3 receptor|neurokinin B receptor|neurokinin beta receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TACR3, check out the TACR3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TACR3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NK3R TACR3 Antibody (A04916)
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