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Product Info Summary
| SKU: | A13349 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-MYOZAP MYZAP Antibody
SKU/Catalog Number
A13349
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-MYOZAP MYZAP Antibody (Catalog # A13349). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
MYOZAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-MYOZAP MYZAP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13349)
Host
Rabbit
Contents
MYOZAP Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
MYOZAP antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human MYOZAP. The immunogen is located within amino acids 400 - 450 of MYOZAP.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of MYOZAP are known to exist.
Reactive Species
A13349 is reactive to MYZAP in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
54206 MW
Background of MYOZAP
MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A13349 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
MYOZAP antibody can be used for detection of MYOZAP by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of MYOZAP in rat kidney tissue lysate with MYOZAP antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of MYOZAP in human lung tissue with MYOZAP antibody at 5 μg/mL.
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Immunofluorescence of MYOZAP in human lung tissue with MYOZAP antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For MYZAP (Source: Uniprot.org, NCBI)
Gene Name
MYZAP
Full Name
Myocardial zonula adherens protein
Weight
54206 MW
Superfamily
MYZAP family
Alternative Names
gcom, Gcom2, MYZAP, GRINL1A, MYZAP-POLR2M, MYOZAP, Myocardial zonula adherens protein, GRINL1A upstream protein, Gup
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MYZAP, check out the MYZAP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MYZAP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MYOZAP MYZAP Antibody (A13349)
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