Product Info Summary
SKU: | A06086-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-Methylosome subunit pICln CLNS1A Antibody
SKU/Catalog Number
A06086-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Methylosome subunit pICln CLNS1A Antibody catalog # A06086-1. Tested in WB,IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Methylosome subunit pICln CLNS1A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06086-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from C-terminal of human CLNS1A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A06086-1 is reactive to CLNS1A in Human
Applications
A06086-1 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
26215 MW
Background of CLNS1A
Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996).
Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995).
Lamb F.S., Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Reconstitution
Restore with deionized water (or equivalent) for reconstitution volume of 100 µL
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:20-1:50
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Methylosome subunit pICln CLNS1A Antibody A06086-1
Western blot analysis of extracts of various cell linesProtein Target Info & Infographic
Gene/Protein Information For CLNS1A (Source: Uniprot.org, NCBI)
Gene Name
CLNS1A
Full Name
Methylosome subunit pICln
Weight
26215 MW
Superfamily
pICln (TC 1.A.47) family
Alternative Names
chloride channel regulatory protein; Chloride channel, nucleotide sensitive 1A; chloride channel, nucleotide-sensitive, 1A; Chloride conductance regulatory protein ICln; Chloride ion current inducer protein; ClCI; CLNS1B; i(Cln); ICln; methylosome subunit pICln; Reticulocyte pICln; reticulocyte protein ICln CLNS1A CLCI, CLNS1B, ICln chloride nucleotide-sensitive channel 1A methylosome subunit pICln|chloride channel regulatory protein|chloride channel, nucleotide sensitive 1A|chloride conductance regulatory protein ICln|chloride ion current inducer protein|i(Cln)|reticulocyte pICln|reticulocyte protein ICln
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CLNS1A, check out the CLNS1A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CLNS1A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Methylosome subunit pICln CLNS1A Antibody (A06086-1)
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