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Product Info Summary
| SKU: | A11870 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-MCG10 PCBP4 Antibody
SKU/Catalog Number
A11870
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-MCG10 PCBP4 Antibody (Catalog # A11870). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
MCG10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-MCG10 PCBP4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11870)
Host
Rabbit
Contents
MCG10 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
MCG10 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human MCG10. The immunogen is located within the last 50 amino acids of MCG10.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.
Reactive Species
A11870 is reactive to PCBP4 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
41482 MW
Background of MCG10
MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11870 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
MCG10 antibody can be used for detection of MCG10 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of MCG10 in HeLa cell lysate with MCG10 antibody at (A) 0.5
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Immunocytochemistry of MCG10 in HeLa cells with MCG10 antibody at 1 μg/mL.
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Immunofluorescence of MCG10 in Hela cells with MCG10 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PCBP4 (Source: Uniprot.org, NCBI)
Gene Name
PCBP4
Full Name
Poly(rC)-binding protein 4
Weight
41482 MW
Alternative Names
CBP, LIP4, MCG10Alpha-CP4 PCBP4 CBP, LIP4, MCG10 poly(rC) binding protein 4 poly(rC)-binding protein 4|LYST-interacting protein|RNA binding protein MCG10|alpha-CP4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PCBP4, check out the PCBP4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PCBP4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MCG10 PCBP4 Antibody (A11870)
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