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Product Info Summary
| SKU: | A06452 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LZTR2 SEC16B Antibody
SKU/Catalog Number
A06452
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LZTR2 SEC16B Antibody (Catalog # A06452). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LZTR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LZTR2 SEC16B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06452)
Host
Rabbit
Contents
LZTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LZTR2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LZTR2. The immunogen is located within the last 50 amino acids of LZTR2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.
Reactive Species
A06452 is reactive to SEC16B in Human, Mouse, Rat
Applications
A06452 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
116604 MW
Background of LZTR2
LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LZTR2 antibody can be used for detection of LZTR2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of LZTR2 in mouse kidney tissue with LZTR2 antibody at 5 μg/mL.
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Immunofluorescence of LZTR2 in mouse kidney tissue with LZTR2 antibody at 20 μg/mL.
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WB Validation in 293 Cells Loading: 10 µg of cell lysate Antibodies 0.5 ug/ml, 1 h incubation at RT in 5% NFDM/TBST.Secondary: Goat Anti-Rabbit IgG HRP conjugate at 1:10000 dilution.Exposure: 10 secLane 1: In the absence of peptide blockingLane 2: In the presence of peptide blocking
Protein Target Info & Infographic
Gene/Protein Information For SEC16B (Source: Uniprot.org, NCBI)
Gene Name
SEC16B
Full Name
Protein transport protein Sec16B
Weight
116604 MW
Superfamily
SEC16 family
Alternative Names
DKFZp686C2486; FLJ23871; FLJ25761; KIAA1928; Leucine zipper transcription regulator 2FLJ36620; LZTR2SEC16Sprotein SEC16 homolog B; PGPR-p117; protein transport protein Sec16B; Regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein; RGPRFLJ33652; RGPR-p117; SEC16 homolog B (S. cerevisiae); SEC16 homolog B SEC16B LZTR2, PGPR-p117, RGPR, RGPR-p117, SEC16S SEC16 homolog B, endoplasmic reticulum export factor protein transport protein Sec16B|leucine zipper transcription regulator 2|protein SEC16 homolog B|regucalcin gene promoter region-related protein p117|regucalcin gene promotor region related protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SEC16B, check out the SEC16B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SEC16B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LZTR2 SEC16B Antibody (A06452)
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