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Product Info Summary
| SKU: | A11486 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LRRTM2 Antibody
SKU/Catalog Number
A11486
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LRRTM2 Antibody (Catalog # A11486). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LRRTM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LRRTM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11486)
Host
Rabbit
Contents
LRRTM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LRRTM2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LRRTM2. The immunogen is located within the last 50 amino acids of LRRTM2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
LRRTM2 antibody is predicted to not cross-react with other LRRTM family members.
Reactive Species
A11486 is reactive to LRRTM2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
59076 MW
Background of LRRTM2
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11486 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LRRTM2 antibody can be used for detection of LRRTM2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LRRTM2 in SK-N-SH cell lysate with LRRTM2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of LRRTM2 in human brain tissue with LRRTM2 antibody at 2.5 μg/mL.
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Immunofluorescence of LRRTM2 in human brain tissue with LRRTM2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LRRTM2 (Source: Uniprot.org, NCBI)
Gene Name
LRRTM2
Full Name
Leucine-rich repeat transmembrane neuronal protein 2
Weight
59076 MW
Superfamily
LRRTM family
Alternative Names
KIAA0416, LRRN2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein LRRTM2 leucine rich repeat transmembrane neuronal 2 leucine-rich repeat transmembrane neuronal protein 2|leucine-rich repeat neuronal 2 protein|leucine-rich repeat transmembrane neuronal 2 protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LRRTM2, check out the LRRTM2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LRRTM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LRRTM2 Antibody (A11486)
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