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Product Info Summary
| SKU: | A12305 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-LGI4 Antibody
SKU/Catalog Number
A12305
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LGI4 Antibody (Catalog # A12305). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LGI4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LGI4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12305)
Host
Rabbit
Contents
LGI4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LGI4 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LGI4. The immunogen is located within amino acids 470 - 520 of LGI4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.
Reactive Species
A12305 is reactive to LGI4 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
59141 MW
Background of LGI4
The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12305 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LGI4 antibody can be used for the detection of LGI4 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LGI4 in rat brain tissue lysate with LGI4 antibody at (A) 1 and (B) 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LGI4 (Source: Uniprot.org, NCBI)
Gene Name
LGI4
Full Name
Leucine-rich repeat LGI family member 4
Weight
59141 MW
Alternative Names
LGIL3, LGIL3, UNQ6515/PRO21485, Leucine-rich repeat LGI family member 4, LGI1-like protein 3 LGI4 AMC1, AMCNMY, LGIL3 leucine rich repeat LGI family member 4 leucine-rich repeat LGI family member 4|LGI1-like protein 3|leucine-rich glioma-inactivated gene 4|leucine-rich glioma-inactivated protein 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LGI4, check out the LGI4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LGI4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LGI4 Antibody (A12305)
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