Product Info Summary
SKU: | A00715 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Laforin EPM2A Antibody
View all Laforin/EPM2A Antibodies
SKU/Catalog Number
A00715
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Laforin EPM2A Antibody (Catalog # A00715). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
EPM2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Laforin EPM2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00715)
Host
Rabbit
Contents
EPM2A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
EPM2A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human EPM2A. The immunogen is located within amino acids 190 - 240 of EPM2A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of EPM2A are known to exist; this antibody will detect all but the shortest isoform.
Reactive Species
A00715 is reactive to EPM2A in Human, Mouse, Rat
Applications
A00715 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
37158 MW
Background of Laforin/EPM2A
The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SW480 in SW480 cell lysate with EPM2A antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of EPM2A in SW480 cells with EPM2A antibody at 2.5 μg/ml.
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Immunofluorescence of EPM2A in SW480 cells with EPM2A antibody at 5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For EPM2A (Source: Uniprot.org, NCBI)
Gene Name
EPM2A
Full Name
Laforin, isoform 9
Weight
37158 MW
Alternative Names
EC 3.1.3.16; EC 3.1.3.48; epilepsy, progressive myoclonus type 2, Lafora disease (laforin); epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); EPM2; EPM2A; Lafora PTPase; Laforin; LAFPTPase; LD; LDE; MELF EPM2A EPM2, MELF EPM2A glucan phosphatase, laforin laforin|EPM2A, laforin glucan phosphatase|LAFPTPase|epilepsy, progressive myoclonus type 2, Lafora disease (laforin)|epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)|glucan phosphatase|glycogen phosphatase|lafora PTPase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on EPM2A, check out the EPM2A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for EPM2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Laforin EPM2A Antibody (A00715)
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