Product Info Summary
SKU: | A01830-2 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, WB |
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Product info
Product Name
Anti-L-dopachrome tautomerase DCT Antibody
SKU/Catalog Number
A01830-2
Size
100ul
Form
Liquid
Description
Boster Bio Anti-L-dopachrome tautomerase DCT Antibody catalog # A01830-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-L-dopachrome tautomerase DCT Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01830-2)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthetic peptide from human DCT protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01830-2 is reactive to DCT in Human, Mouse, Rat
Applications
A01830-2 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
59145 MW
Background of TRP2
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
Mittaz L., Genomics 41:210-217(1997).
Lai F., Mol. Cell. Biol. 17:2413-2424(1997).
Villard L., Somat. Cell Mol. Genet. 23:135-145(1997).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-2000
ELISA 1:10000-20000
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of DCT using Anti-L-dopachrome tautomerase DCT Antibody (A01830-2).
Immunohistochemical analysis of paraffin-embedded human-breast-cancerClick image to see more details
Figure 1. Western blotting validation for Anti-L-dopachrome tautomerase DCT Antibody A01830-2
Western blot analysis of HELA A549 Cell LysateProtein Target Info & Infographic
Gene/Protein Information For DCT (Source: Uniprot.org, NCBI)
Gene Name
DCT
Full Name
L-dopachrome tautomerase
Weight
59145 MW
Superfamily
tyrosinase family
Alternative Names
dopachrome delta-isomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; EC 5.3.3.12; L-dopachrome tautomerase; TRP2; TRP-2; Tyrosinase-related protein 2; TYRP2; TYRP2L-dopachrome Delta-isomerase DCT OCA8, TRP-2, TYRP2 dopachrome tautomerase L-dopachrome tautomerase|DT|L-dopachrome Delta-isomerase|L-dopachrome isomerase|TRP2|dopachrome delta-isomerase|dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)|tyrosinase related protein-2|tyrosine-related protein 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DCT, check out the DCT Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DCT: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-L-dopachrome tautomerase DCT Antibody (A01830-2)
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