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Product Info Summary
| SKU: | A02850 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-JMJD2A KDM4A Antibody
SKU/Catalog Number
A02850
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-JMJD2A KDM4A Antibody (Catalog # A02850). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
JMJD2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-JMJD2A KDM4A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02850)
Host
Rabbit
Contents
JMJD2A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
JMJD2A antibody was raised against a 14 amino acid synthetic peptide from near the center of human JMJD2A. The immunogen is located within amino acids 340 - 390 of JMJD2A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
WWC1 antibody is human, mouse and rat reactive. At least three isoforms of WWC1 are known to exist; this antibody will detect all three isoforms.
Reactive Species
A02850 is reactive to KDM4A in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
120662 MW
Background of KDM4A
Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02850 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
JMJD2A antibody can be used for detection of JMJD2A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of JMJD2A in rat liver tissue lysate with JMJD2A antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of JMJD2A in rat liver tissue with JMJD2A antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For KDM4A (Source: Uniprot.org, NCBI)
Gene Name
KDM4A
Full Name
Lysine-specific demethylase 4A
Weight
120662 MW
Superfamily
JHDM3 histone demethylase family
Alternative Names
JMJD2, JHDM3A, JMJD2A, TDRD14A, JMJD2, KIAA0677, Lysine-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A KDM4A JHDM3A, JMJD2, JMJD2A, TDRD14A lysine demethylase 4A lysine-specific demethylase 4A|[histone H3]-trimethyl-L-lysine(36) demethylase 4A|[histone H3]-trimethyl-L-lysine(9) demethylase 4A|jmjC domain-containing histone demethylation protein 3A|jumonji C domain-containing histone demethylase 3A|jumonji domain containing 2|jumonji domain containing 2A|jumonji domain-containing protein 2A|lysine (K)-specific demethylase 4A|tudor domain containing 14A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KDM4A, check out the KDM4A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KDM4A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-JMJD2A KDM4A Antibody (A02850)
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