Anti-Indoleamine 2,3-dioxygenase 2 IDO2 Antibody

Product Name

Anti-Indoleamine 2,3-dioxygenase 2 IDO2 Antibody

View all IDO2 Antibodies

SKU/Catalog Number

A06002-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Indoleamine 2,3-dioxygenase 2 IDO2 Antibody catalog # A06002-1. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Indoleamine 2,3-dioxygenase 2 IDO2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06002-1)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human S10AD protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A06002-1 is reactive to IDO2 in Human, Mouse, Rat

Applications

A06002-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

47075 MW

Background of IDO2

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Lizcano J.M., EMBO J. 23:833-843(2004).
Lu R., J. Biol. Chem. 279:31164-31170(2004).
Nagase T., DNA Res. 8:85-95(2001).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:1000

Validation Images & Assay Conditions

Click image to see more details

Figure 1. Western blotting validation for Anti-Indoleamine 2

Gene/Protein Information For IDO2 (Source: Uniprot.org, NCBI)

Alternative Names

EC 1.13.11.-; IDO2; Ido-2; INDOL1; INDOL1indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine 2,3-dioxygenase 2; Indoleamine 2,3-dioxygenase-2; indoleamine 2,3-dioxygenase-like 1 protein; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1 IDO2 INDOL1 indoleamine 2,3-dioxygenase 2 indoleamine 2,3-dioxygenase 2|indoleamine 2,3-dioxygenase-like 1 protein|indoleamine 2,3-dioxygenase-like protein 1|indoleamine-pyrrole 2,3 dioxygenase-like 1|indoleamine-pyrrole 2,3-dioxygenase-like protein 1

For more info on IDO2, check out the IDO2 Infographic

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In this infographic, you will see the following information for IDO2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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