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Product Info Summary
| SKU: | A06131 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Importin subunit alpha-4 KPNA3 Antibody
SKU/Catalog Number
A06131
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Importin subunit alpha-4 KPNA3 Antibody (Catalog # A06131). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
KPNA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Importin subunit alpha-4 KPNA3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06131)
Host
Rabbit
Contents
KPNA3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
KPNA3 antibody was raised against a 14 amino acid synthetic peptide near the carboxy end of human KPNA3. The immunogen is located within the last 50 amino acids of KPNA3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
OLIG1 antibody is human specific. It is predicted to not cross-react with other members of the OLIG family of proteins.
Reactive Species
A06131 is reactive to KPNA3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
57811 MW
Background of KPNA3
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA3, the alpha subunit 3 of karyopherin, is silimar to human KPNA2, suggesting that KPNA3 may be involved in the nuclear transport system. It is ubiquitously expressed and recent studies have shown that human KPNA3 may be associated with schizophrenia.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06131 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
KPNA3 antibody can be used for detection of KPNA3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of KPNA3 in EL4 cell lysate with KPNA3 antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of KPNA3 in HeLa cells with KPNA3 antibody at 10 μg/mL.
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Immunofluorescence of KPNA3 in EL4 cells with KPNA3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For KPNA3 (Source: Uniprot.org, NCBI)
Gene Name
KPNA3
Full Name
Importin subunit alpha-4
Weight
57811 MW
Superfamily
importin alpha family
Alternative Names
SRP1, SRP4, IPOA4, hSRP1, SRP1gamma, QIP2, Importin subunit alpha-4, Importin alpha Q2, Qip2 KPNA3 IPOA4, SRP1, SRP1gamma, SRP4, hSRP1 karyopherin subunit alpha 3 importin subunit alpha-4|SRP1-gamma|importin alpha 4|importin alpha Q2|importin alpha-3|importin subunit alpha-3|karyopherin alpha 3 (importin alpha 4)|qip2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KPNA3, check out the KPNA3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KPNA3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Importin subunit alpha-4 KPNA3 Antibody (A06131)
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