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Product Info Summary
| SKU: | A05005 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-IA-1 INSM1 Antibody
SKU/Catalog Number
A05005
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IA-1 INSM1 Antibody (Catalog # A05005). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
IA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-IA-1 INSM1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05005)
Host
Rabbit
Contents
IA-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IA-1 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human IA-1. The immunogen is located within amino acids 90 - 140 of IA-1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SKI2W antibody is human, mouse and rat reactive. At least two isoforms of SKI2W are known to exist; this antibody will detect both isoforms.
Reactive Species
A05005 is reactive to INSM1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
52923 MW
Background of INSM1
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05005 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IA-1 antibody can be used for detection of IA-1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For INSM1 (Source: Uniprot.org, NCBI)
Gene Name
INSM1
Full Name
Insulinoma-associated protein 1
Weight
52923 MW
Superfamily
INSM1 family
Alternative Names
IA1, IA-1, IA1, Insulinoma-associated protein 1, Zinc finger protein IA-1 INSM1 IA-1, IA1 INSM transcriptional repressor 1 insulinoma-associated protein 1|insulinoma-associated 1|zinc finger protein IA-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on INSM1, check out the INSM1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for INSM1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IA-1 INSM1 Antibody (A05005)
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