Click image to see more details
Product Info Summary
| SKU: | FC04065-PE-Cy7 |
|---|---|
| Size: | 100 tests, 200 tests |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry |
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Product info
Product Name
Anti-human CD10 MME Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated
View all Neprilysin/CD10 Antibodies
SKU/Catalog Number
FC04065-PE-Cy7
Size
100 tests, 200 tests
Form
Liquid
Description
Boster Bio Anti-human CD10 MME Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated (Catalog# FC04065-PE-Cy7). Tested in Flow Cytometry application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-human CD10 MME Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated (Boster Biological Technology, Pleasanton CA, USA, Catalog # FC04065-PE-Cy7)
Host
Mouse
Contents
PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide
Clonality
Monoclonal
Clone Number
Clone: FR4D11
Isotype
IgG1,k
Immunogen
Raji cells
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
FC04065-PE-Cy7 is reactive to MME in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
85514 MW
Background of Neprilysin/CD10
CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, or common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
FC04065-PE-Cy7 is guaranteed for Flow Cytometry Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow Cytometry, 5μl is enough to stain 1 million PBMCs or 100μl whole blood sample
Validation Images & Assay Conditions
Click image to see more details
Anti-human CD10 PE-Cy7 Conjugated, Flow Validated
Reh cells were stained with PE-Cyanine 7
conjugated anti-human CD10 (clone FR4D11)
(red histogram). Reh cells stained with PECyanine
7 conjugated mouse IgG1 isotype
control (Blue histogram). The data are generated
in BD Accuri C6 and analyzed by FlowJo software.
Protein Target Info & Infographic
Gene/Protein Information For MME (Source: Uniprot.org, NCBI)
Gene Name
MME
Full Name
Neprilysin
Weight
85514 MW
Superfamily
peptidase M13 family
Alternative Names
Neprilysin;3.4.24.11 ;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD10;MME;EPN; MME CALLA, CD10, CMT2T, NEP, SCA43, SFE membrane metalloendopeptidase neprilysin|atriopeptidase|common acute lymphocytic leukemia |membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase variant 1|membrane metallo-endopeptidase variant 2|neprilysin-390|neprilysin-411|neutral endopeptidase 24.11|skin fibroblast elastase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MME, check out the MME Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MME: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-human CD10 MME Monoclonal Antibody PE-Cy7 Conjugated, Flow Validated (FC04065-PE-Cy7)
Hello CJ!
FC04065-PE-Cy7 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
A metanephric adenoma of the kidney associated with polycythemia: A case report
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