Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody

Product Name

Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody

View all ITGA2B Antibodies

SKU/Catalog Number

M01102-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody (Catalog# M01102-1). Tested in Flow Cytometry, IHC-F application(s). This antibody reacts with Primate, Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01102-1)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

HIP8

Isotype

Mouse IgG1

Immunogen

The antibody HIP8 reacts with an extracellular epitope on alpha (a) subunit of CD41 (heavy chain; 120 kDa). CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies o platelets and megakaryocytes.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01102-1 is reactive to ITGA2B in Human, Primate

Reconstitution

Observed Molecular Weight

42 kDa

Calculated molecular weight

113377 MW

Background of ITGA2B

CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M01102-1 is guaranteed for Flow Cytometry, IHC-F Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1-4 µg/ml

Validation Images & Assay Conditions

Gene/Protein Information For ITGA2B (Source: Uniprot.org, NCBI)

Alternative Names

GT, GTA, GP2B, HPA3, GPIIb ITGA2B BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93 integrin subunit alpha 2b integrin alpha-IIb|GPalpha IIb|alphaIIb protein|integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, CD41)|platelet fibrinogen receptor, alpha subunit|platelet glycoprotein IIb of IIb/IIIa complex|platelet membrane glycoprotein IIb|platelet-specific BAK|protein phosphatase 1, regulatory subunit 93

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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