Product Info Summary
SKU: | M07727 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human |
Host: | Mouse |
Application: | Flow Cytometry, IP, IHC, WB |
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Product info
Product Name
Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody
View all TSPAN7/TM4SF2 Antibodies
SKU/Catalog Number
M07727
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (Catalog# M07727). Tested in Flow Cytometry, IP, WB, IHC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M07727)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
B2D
Isotype
Mouse IgG1
Immunogen
Human T-ALL cell line THP-6. The mouse monoclonal antibody B2D recognizes an extracellular epitope of CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Reactive Species
M07727 is reactive to TSPAN7 in Human
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
27574 MW
Background of TSPAN7/TM4SF2
CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M07727 is guaranteed for Flow Cytometry, IP, IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry: Positive control: brain.
Flow cytometry: 1-4 µg/ml
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Flow Cytometry validation of TSPAN7 using Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (M07727).
Flow cytometry analysis (surface staining) of CD231 in JURKAT cells with anti-CD231 (B2D) purifiedProtein Target Info & Infographic
Gene/Protein Information For TSPAN7 (Source: Uniprot.org, NCBI)
Gene Name
TSPAN7
Full Name
Tetraspanin-7
Weight
27574 MW
Superfamily
tetraspanin (TM4SF) family
Alternative Names
TSPAN7, TALLA-1, MXS1, MRX58, TM4SF2 TSPAN7 A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b tetraspanin 7 tetraspanin-7|CD231 |T-cell acute lymphoblastic leukemia associated 1|cell surface glycoprotein A15|membrane component chromosome X surface marker 1|membrane component, X chromosome, surface marker 1|tetraspanin protein|transmembrane 4 superfamily 2b|transmembrane 4 superfamily member 2|transmembrane protein A15|tspan-7
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TSPAN7, check out the TSPAN7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TSPAN7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (M07727)
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