Anti-HIF1AN Antibody (C-term)

FIH-1/HIF-1AN antibody

Boster Bio Anti-HIF1AN Antibody (C-term) (Catalog # M02116-1). Tested in WB, IF application(s). This antibody reacts with Human.

Product Info Summary

SKU: M02116-1
Size: 50 µl
Reactive Species: Human
Host: Mouse
Application: IF, WB

Product Name

Anti-HIF1AN Antibody (C-term)

View all FIH-1/HIF-1AN Antibodies

SKU/Catalog Number

M02116-1

Size

50 µl

Description

Boster Bio Anti-HIF1AN Antibody (C-term) (Catalog # M02116-1). Tested in WB, IF application(s). This antibody reacts with Human.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-HIF1AN Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02116-1)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Monoclonal

Clone Number

931CT3.1.1

Isotype

IgG1,k

Immunogen

This HIF1AN antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-349 amino acids from human HIF1AN.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M02116-1 is reactive to HIF1AN in Human

Reconstitution

Calculated molecular weight

40285 Da

Background of FIH-1/HIF-1AN

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M02116-1 is guaranteed for IF, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IF: 1:25
WB: 1:4000

Validation Images & Assay Conditions

Gene/Protein Information For HIF1AN (Source: Uniprot.org, NCBI)

Gene Name

HIF1AN

Full Name

Hypoxia-inducible factor 1-alpha inhibitor

Weight

40285 Da

Alternative Names

Hypoxia-inducible factor 1-alpha inhibitor, 1.14.11.30, 1.14.11.n4, Factor inhibiting HIF-1, FIH-1, Hypoxia-inducible factor asparagine hydroxylase, HIF1AN, FIH1 HIF1AN FIH1 hypoxia inducible factor 1 subunit alpha inhibitor hypoxia-inducible factor 1-alpha inhibitor|FIH-1|factor inhibiting HIF-1|factor inhibiting HIF1|hypoxia inducible factor 1 alpha subunit inhibitor|hypoxia-inducible factor asparagine hydroxylase|peptide-aspartate beta-dioxygenase

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on HIF1AN, check out the HIF1AN Infographic

HIF1AN infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for HIF1AN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M02116-1-50ul

50 μl

$299
M02116-1-200ul

200 μl

$347

Free Secondary Antibody

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M02116-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$299.00

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