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Key=sku, value=A00827-1
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Key=created_at, value=2020-03-11 06:18:47
Key=updated_at, value=2024-09-26 01:02:54
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Key=status, value=Enabled
Key=name, value=Anti-GTP-binding protein Rheb Rheb Antibody
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Key=price, value=449.0000
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Key=meta_title, value=GTP-binding protein Rheb Rheb Antibody A00827-1
Key=meta_description, value=Boster Bio Anti-GTP-binding protein Rheb Rheb Antibody (Catalog # A00827-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat. Supplied as 0.1 mg in Liquid form antibody.
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Key=url_key, value=anti-gtp-binding-protein-rheb-rheb-antibody-a00827-1-boster
Key=url_path, value=anti-il-8-antibody-a00423-boster
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Key=size, value=0.1 mg
Key=protein_name, value=Ras homolog enriched in brain
Key=gene_full_name, value=Ras homolog enriched in brain
Key=uniprot_id, value=Q15382
Key=sensitivity
Key=applications, value=ELISA, IF, IHC-P, WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Liquid
Key=concentration, value=1 mg/mL
Key=cross_reactivity, value=Post-translationally modified Rheb is sometimes observed at higher molecular weight.
Key=clone_number
Key=predicted_reactivity, value=Bovine
Key=source_company, value=Prosci 3501; Cost: 249
Key=isotype, value=IgG
Key=molecular_weight, value=20497 MW
Key=sample_size_available, value=25ug for $99, contact us for details
Key=related_product_skus, value=EK0413,PB9621,PROTP10145,PROTP10145-1,PROTP10145-2,PROTP10145-3,PROTP19874,PROTP26894,PROTP41324,PROTP67813
Key=product_category, value=Primary Antibodies
Key=research_category, value=Cancer, Signal Transduction
Key=clonality, value=Polyclonal
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Key=cj_related_products, value=Response To Nutrient:PB9795^Thoracic Outlet Syndrome:A30682|A01463-3|P03629|M03629^Tuberous Sclerosis:A01118-1
Key=description, value=Boster Bio Anti-GTP-binding protein Rheb Rheb Antibody (Catalog # A00827-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Key=short_description, value=Boster Bio Anti-GTP-binding protein Rheb Rheb Antibody (Catalog # A00827-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Key=meta_keyword, value=Anti-GTP-binding protein Rheb Rheb Antibody
Key=contents, value=Rheb Antibody is supplied in PBS containing 0.02% sodium azide.
Key=background, value=Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.
Key=gene_name, value=RHEB
Key=synonyms, value=RHEB2, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain
Key=application_details, value=Rheb antibody can be used for the detection of Rheb by Western blot at 1 to 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Key=subcellular_localization, value=Endomembrane system
Key=tissue_specificity, value=Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Key=protein_function, value=Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Key=application_notes
Key=description_before_attributes
Key=competitor_equivalent_skus, value=sc 25342|sc 55462|sc 7165|sc 4600|sc 73321|sc 7922|sc 1269|sc 376750|sc 8427|sc 7302|sc 52870|sc 101499|sc 32817|sc 71367
Key=immunogen, value=Rheb antibody was raised against a 15 amino acid synthetic peptide from the middle region of human Rheb. The immunogen is located within amino acids 40 - 90 of Rheb.
Key=purification, value=Rheb Antibody is affinity chromatography purified via peptide column.
Key=storage, value=Rheb antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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