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Product Info Summary
| SKU: | A13341 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Grik5 Antibody
View all KA2/GRIK5/Glutamate Receptor KA2 Antibodies
SKU/Catalog Number
A13341
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Grik5 Antibody (Catalog # A13341). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Grik5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Grik5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13341)
Host
Rabbit
Contents
Grik5 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Grik5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Grik5. The immunogen is located within the last 50 amino acids of Grik5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This Grik5 antibody does not cross-react with Grik4.
Reactive Species
A13341 is reactive to GRIK5 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
109265 MW
Background of KA2/GRIK5/Glutamate Receptor KA2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A13341 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Grik5 antibody can be used for detection of Grik5 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Grik5 in human brain tissue lysate with Grik5 antibody at (A) 0.5
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Immunohistochemical staining of human brain tissue using Grik5 antibody at 2.5 μg/mL.
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Immunofluorescence of Grik5 in Human Brain cells with Grik5 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GRIK5 (Source: Uniprot.org, NCBI)
Gene Name
GRIK5
Full Name
Glutamate receptor ionotropic, kainate 5
Weight
109265 MW
Superfamily
glutamate-gated ion channel (TC 1.A.10.1) family
Alternative Names
KA2, EAA2, GRIK2, GluK5, Glutamate receptor ionotropic, kainate 5, Excitatory amino acid receptor 2 GRIK5 EAA2, GRIK2, GluK5, KA2 glutamate ionotropic receptor kainate type subunit 5 glutamate receptor ionotropic, kainate 5|excitatory amino acid receptor 2|glutamate receptor KA2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRIK5, check out the GRIK5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRIK5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Grik5 Antibody (A13341)
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