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Product Info Summary
| SKU: | A09195 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Grik4 Antibody
View all KA1/GRIK4/Glutamate Receptor KA1 Antibodies
SKU/Catalog Number
A09195
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Grik4 Antibody (Catalog # A09195). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Grik4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Grik4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09195)
Host
Rabbit
Contents
Grik4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Grik4 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the mouse Grik4. The immunogen is located within the last 50 amino acids of Grik4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TOM70 are known to exist; this antibody will only detect the larger isoform.
Reactive Species
A09195 is reactive to GRIK4 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
107264 MW
Background of KA1/GRIK4/Glutamate Receptor KA1
Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09195 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Grik4 antibody can be used for detection of Grik4 by Western blot at 0.5 - 2 μg/mL. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Grik4 in rat brain lysate with Grik4 antibody at (A) 0.5 (B) 1 and (C) 2 μg/mL.
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Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 μg/mL.
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Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GRIK4 (Source: Uniprot.org, NCBI)
Gene Name
GRIK4
Full Name
Glutamate receptor ionotropic, kainate 4
Weight
107264 MW
Superfamily
glutamate-gated ion channel (TC 1.A.10.1) family
Alternative Names
KA1, EAA1, GRIK, GluK4, Glutamate receptor ionotropic, kainate 4, Excitatory amino acid receptor 1 GRIK4 EAA1, GRIK, GluK4, KA1 glutamate ionotropic receptor kainate type subunit 4 glutamate receptor ionotropic, kainate 4|excitatory amino acid receptor 1|glutamate receptor KA1|glutamate receptor, ionotropic, kainate 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRIK4, check out the GRIK4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRIK4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Grik4 Antibody (A09195)
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