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Product Info Summary
| SKU: | A02208 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-GPVI GP6 Antibody
SKU/Catalog Number
A02208
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-GPVI GP6 Antibody (Catalog # A02208). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
GPVI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-GPVI GP6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02208)
Host
Rabbit
Contents
GPVI Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
GPVI antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of isoform 2 of the human GPVI. The immunogen is located within the last 50 amino acids of GPVI.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three GPVI isoforms are known to exist; this antibody will detect the two longest isoforms. Because of its extensive glycosylation, GPVI often migrates at a higher than expected molecular weight in SDS-PAGE.
Reactive Species
A02208 is reactive to GP6 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
36866 MW
Background of GPVI
Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02208 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
GPVI antibody can be used for detection of GPVI by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of GPVI in K562 cell lysate with GPVI antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 μg/mL.
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Immunofluorescence of GPVI in Human Heart tissue with GPVI antibody at 20 μg/mL.
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Western blot analysis of GPVI in HeLa (A) and Jurkat (B) with GPVI antibody at 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GP6 (Source: Uniprot.org, NCBI)
Gene Name
GP6
Full Name
Platelet glycoprotein VI
Weight
36866 MW
Alternative Names
GPIV, GPVI, BDPLT11, Platelet glycoprotein VI, Glycoprotein 6 GP6 BDPLT11, GPIV, GPVI glycoprotein VI platelet platelet glycoprotein VI|glycoprotein 6|platelet collagen receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GP6, check out the GP6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GP6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GPVI GP6 Antibody (A02208)
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