Anti-GPRC6A Antibody

Product Name

Anti-GPRC6A Antibody

View all Gprc6a Antibodies

SKU/Catalog Number

A05697

Size

100μl

Form

Liquid

Description

Boster Bio Anti-GPRC6A Antibody catalog # A05697. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-GPRC6A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05697)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

1E3

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human GPRC6A. at AA rangle: 440-520

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A05697 is reactive to Gprc6a in Human

Applications

A05697 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

104753 MW

Background of Gprc6a

ROC2 also known as RING-box protein 2, Rbx2, RING finger protein 7, Regulator of cullins 2, CKII beta-binding protein 1, and CKBBP1, is a probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC2 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. ROC2 may play a role in protecting cells from apoptosis induced by redox agents. ROC2 has a cytoplasmic and nuclear localization and is expressed in heart, liver, skeletal muscle and pancreas tissues, and at very low levels in brain, placenta and lung. 1,10-phenanthroline induces ROC2 expression. The RING-type zinc finger domain is essential for ubiquitin ligase activity. Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of specific cells using antibody diluted at 1:1000.

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Western Blot (WB) analysis of Jurkat cells using GPRC6A Polyclonal antibody.

Gene/Protein Information For Gprc6a (Source: Uniprot.org, NCBI)

Alternative Names

bA86F4.3; G protein-coupled receptor, family C, group 6, member A; GPCR; GPCR33; GPRC6A; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33; hGPCR33; hGPRC6A; predicted with SOSUI analysis; seven transmembrane helix receptor Gprc6a|G protein-coupled receptor, family C, group 6, member A|G-protein coupled receptor family C group 6 member A

For more info on Gprc6a, check out the Gprc6a Infographic

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In this infographic, you will see the following information for Gprc6a: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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