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Product Info Summary
| SKU: | A04408 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-GITRL TNFSF18 Antibody
View all GITR Ligand/TNFSF18 Antibodies
SKU/Catalog Number
A04408
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-GITRL TNFSF18 Antibody (Catalog # A04408). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
GITRL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-GITRL TNFSF18 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04408)
Host
Rabbit
Contents
GITRL Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
GITRL antibody was raised against purified recombinant human GITR ligand.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This BICD2 antibody will not cross-react with BICD1.
Reactive Species
A04408 is reactive to TNFSF18 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
22724 MW
Background of GITR Ligand/TNFSF18
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04408 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
GITRL antibody can be used for the detection of GITRL by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 μg/mL.
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Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TNFSF18 (Source: Uniprot.org, NCBI)
Gene Name
TNFSF18
Full Name
Tumor necrosis factor ligand superfamily member 18
Weight
22724 MW
Superfamily
tumor necrosis factor family
Alternative Names
TL6, AITRL, GITRL, hGITRL, TL6, UNQ149/PRO175, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand TNFSF18 AITRL, GITRL, TL6, TNLG2A, hGITRL TNF superfamily member 18 tumor necrosis factor ligand superfamily member 18|AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor (ligand) superfamily, member 18|tumor necrosis factor ligand 2A|tumor necrosis factor superfamily member 18
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TNFSF18, check out the TNFSF18 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TNFSF18: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GITRL TNFSF18 Antibody (A04408)
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