Product Info Summary
SKU: | A10887 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human |
Host: | Rabbit |
Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-FRMPD1 Antibody
SKU/Catalog Number
A10887
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FRMPD1 Antibody (Catalog # A10887). Tested in ELISA, WB, IF applications. This antibody reacts with Human.
Storage & Handling
FRMPD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-FRMPD1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10887)
Host
Rabbit
Contents
FRMPD1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
FRMPD1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human FRMPD1. The immunogen is located within amino acids 1330 - 1380 of FRMPD1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TNFAIP2 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with TNFAIP3.
Reactive Species
A10887 is reactive to FRMPD1 in Human
Applications
A10887 is guaranteed for ELISA, IF, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
173437 MW
Background of FRMPD1
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FRMPD1 antibody can be used for detection of FRMPD1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of FRMPD1 in K562 cell lysate with FRMPD1 antibody at (A) 1 and (B) 2 μg/mL.
Click image to see more details
Immunofluorescence of FRMPD1 in K562 cells with FRMPD1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FRMPD1 (Source: Uniprot.org, NCBI)
Gene Name
FRMPD1
Full Name
FERM and PDZ domain-containing protein 1
Weight
173437 MW
Alternative Names
FERM and PDZ domain containing 1; FERM and PDZ domain-containing protein 1; FRMD2KIAA0967FERM domain-containing protein 2; MGC138833 FRMPD1 FRMD2 FERM and PDZ domain containing 1 FERM and PDZ domain-containing protein 1|FERM domain-containing protein 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FRMPD1, check out the FRMPD1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FRMPD1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FRMPD1 Antibody (A10887)
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