Anti-FAIM Antibody

Product Name

Anti-FAIM Antibody

View all FAIM1 Antibodies

SKU/Catalog Number

A10908

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-FAIM Antibody (Catalog # A10908). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

FAIM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-FAIM Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10908)

Host

Rabbit

Contents

FAIM Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

FAIM antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human FAIM. The immunogen is located within the last 50 amino acids of FAIM.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

PDCL2 antibody is human, mouse and rat reactive. PDCL2 antibody is predicted to not cross-react with other members of the PDCL protein family.

Reactive Species

A10908 is reactive to Faim in Human, Mouse

Applications

A10908 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

20215 MW

Background of FAIM1

The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-κB and the Ras-ERK pathway.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

FAIM antibody can be used for detection of FAIM by Western blot at 5 - 10 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of FAIM in human spleen tissue lysate with FAIM antibody at (A) 5 and (B) 10 μg/mL.

Gene/Protein Information For Faim (Source: Uniprot.org, NCBI)

Alternative Names

FAIM1FLJ10582; fas apoptotic inhibitory molecule 1; Fas apoptotic inhibitory molecule Faim|Fai|Fas apoptotic inhibitory molecule|fas apoptotic inhibitory molecule 1

For more info on Faim, check out the Faim Infographic

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In this infographic, you will see the following information for Faim: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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