Anti-EVER1 TMC6 Antibody

Product Name

Anti-EVER1 TMC6 Antibody

View all TMC6 Antibodies

SKU/Catalog Number

A07322

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-EVER1 TMC6 Antibody (Catalog # A07322). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

EVER1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-EVER1 TMC6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07322)

Host

Rabbit

Contents

EVER1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

EVER1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1. The immunogen is located within the first 50 amino acids of EVER1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Reactive Species

A07322 is reactive to TMC6 in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

90045 MW

Background of TMC6

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A07322 is guaranteed for ELISA, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For TMC6 (Source: Uniprot.org, NCBI)

Alternative Names

EV1, EVER1, EVIN1, LAK-4P, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1 TMC6 EV1, EVER1, EVIN1, LAK-4P, TNRC6C-AS1, lnc transmembrane channel like 6 transmembrane channel-like protein 6|TNRC6C antisense RNA 1|epidermodysplasia verruciformis 1|epidermodysplasia verruciformis protein 1|expressed in activated T/LAK lymphocytes|protein LAK-4

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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