Anti-ERI1/Hexo Antibody

Product Name

Anti-ERI1/Hexo Antibody

View all HEXO Antibodies

SKU/Catalog Number

A07945

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-ERI1/Hexo Antibody (Catalog # A07945). Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-ERI1/Hexo Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07945)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human ERI1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A07945 is reactive to ERI1 in Human

Reconstitution

Calculated molecular weight

40064 MW

Background of HEXO

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Dominski Z., Mol. Cell 12:295-305(2003).
Ota T., Nat. Genet. 36:40-45(2004).
Bechtel S., BMC Genomics 8:399-399(2007)

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A07945 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For ERI1 (Source: Uniprot.org, NCBI)

Alternative Names

3'-5' exoribonuclease 1;3.1.-.-;3'-5' exonuclease ERI1;Eri-1 homolog;Histone mRNA 3'-end-specific exoribonuclease;Histone mRNA 3'-exonuclease 1;Protein 3'hExo;HEXO;ERI1;3'EXO, THEX1; Eri1|3hexo, 3110010F15Rik, Er, Thex1, eri-1|exoribonuclease 1|3-5 exoribonuclease 1|3-5 exonuclease ERI1|enhanced RNAi protein 1|eri-1 homolog|histone mRNA 3 end-specific exonuclease|histone mRNA 3-exonuclease 1|three prime histone mRNA exonuclease 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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