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Product Info Summary
| SKU: | A01784 |
|---|---|
| Size: | 50μg/vial |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-EC SOD SOD3 Antibody
View all SOD3/EC-SOD Antibodies
SKU/Catalog Number
A01784
Size
50μg/vial
Form
Liquid
Description
Boster Bio Anti-EC SOD SOD3 Antibody catalog # A01784. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store beta-Actin Loading Control Antibody at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Cite This Product
Anti-EC SOD SOD3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01784)
Host
Rabbit
Contents
Each vial contains 50% glycerol and 0.09% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthetic peptide corresponding to a portion of EC SOD. The sequence is completely conserved in human, mouse, rat and rabbit.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01784 is reactive to SOD3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
25851 MW
Background of SOD3/EC-SOD
SOD3 (SUPEROXIDE DISMUTASE 3) also called SUPEROXIDE DISMUTASE, EXTRACELLULAR, EC-SOD, and Cu-Zn, is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. Hendrickson et al. (1990) mapped the SOD3 gene to 4pter-q21 by a study of somatic cell hybrids. Stern et al. (2003) narrowed the assignment to 4p15.3-p15.1 by somatic cell and radiation hybrid analysis, linkage mapping, and FISH. The product of this gene is though to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01784 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB, 1:1, 000, ECL, Human, Mouse, Rat
Validation Images & Assay Conditions
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Western blot analysis of EC SOD expression in MW Marker (lane 1), rat lung extract (lane 2), mouse lung extract (lane 3) and Human EC SOD Protein (lane 4). EC SOD at 35-40KD was detected using rabbit anti-EC SOD Antigen Affinity purified polyclonal antibody (Catalog # A01784) at 1:1000. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).
Protein Target Info & Infographic
Gene/Protein Information For SOD3 (Source: Uniprot.org, NCBI)
Gene Name
SOD3
Full Name
Extracellular superoxide dismutase [Cu-Zn]
Weight
25851 MW
Superfamily
Cu-Zn superoxide dismutase family
Alternative Names
Extracellular superoxide dismutase [Cu-Zn];EC-SOD;1.15.1.1;SOD3; SOD3 EC-SOD superoxide dismutase 3 extracellular superoxide dismutase [Cu-Zn]|superoxide dismutase 3, extracellular|testicular tissue protein Li 175
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SOD3, check out the SOD3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SOD3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-EC SOD SOD3 Antibody (A01784)
Hello CJ!
A01784 has been cited in 2 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Epigallocatechin%u20103%u2010Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF%u2010%u03BAB and Nrf2/HO%u20101 Signalling Pathway Regulation
Long Sh, Yu Zq, Shuai L, Guo Yl, Duan Dl, Xu Xy, Li Xd. Int J Mol Sci. 2012;13(3):3354-65. Doi: 10.3390/Ijms13033354. Epub 2012 Mar 12. The Hypoglycemic Effect Of The Kelp On Diabetes Mellitus Model Induced By Alloxan In Rats.
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