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Product Info Summary
| SKU: | A03498 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-DYRK2 Antibody
SKU/Catalog Number
A03498
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DYRK2 Antibody (Catalog # A03498). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
DYRK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DYRK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03498)
Host
Rabbit
Contents
DYRK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DYRK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DYRK2. The immunogen is located within amino acids 520 - 570 of DYRK2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two isoforms of DYRK2 are known to exist; this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.
Reactive Species
A03498 is reactive to DYRK2 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
66652 MW
Background of DYRK2
DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03498 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DYRK2 antibody can be used for detection of DYRK2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DYRK2 in 293 cell lysate with DYRK2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of DYRK2 in 293 cells with DYRK2 antibody at 10 μg/mL.
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Immunofluorescence of DYRK2 in 293 cells with DYRK2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DYRK2 (Source: Uniprot.org, NCBI)
Gene Name
DYRK2
Full Name
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Weight
66652 MW
Superfamily
protein kinase superfamily
Alternative Names
Dual specificity tyrosine-phosphorylation-regulated kinase 2 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 dual specificity tyrosine-phosphorylation-regulated kinase 2|dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DYRK2, check out the DYRK2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DYRK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DYRK2 Antibody (A03498)
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