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Product Info Summary
| SKU: | A00556 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Dynamin-1-like protein DNM1L Antibody
SKU/Catalog Number
A00556
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Dynamin-1-like protein DNM1L Antibody (Catalog # A00556). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
DNM1L antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Dynamin-1-like protein DNM1L Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00556)
Host
Rabbit
Contents
DNM1L antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L. The immunogen is located within amino acids 530 - 580 of DNM1L.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
DNM1L antibody is human and mouse reactive. At least four isoforms of DNM1L are known to exist; this antibody will detect the two longest isoforms.
Reactive Species
A00556 is reactive to DNM1L in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
81877 MW
Background of DRP1
The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1). DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2). Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00556 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DNM1L antibody can be used for detection of DNM1L by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DNM1L in HeLa cell lysate with DNM1L antibody at 1 μg/ml.
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Immunocytochemistry of DNM1L in HeLa cells with DNM1L antibody at 5 μg/mL.
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Immunofluorescence of DNM1L in HeLa cells with DNM1L antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DNM1L (Source: Uniprot.org, NCBI)
Gene Name
DNM1L
Full Name
Dynamin-1-like protein
Weight
81877 MW
Superfamily
TRAFAC class dynamin-like GTPase superfamily
Alternative Names
DLP1, DRP1, DVLP, EMPF, DYMPLE, HDYNIV, DLP1, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less DNM1L DLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5 dynamin 1 like dynamin-1-like protein|Dnm1p/Vps1p-like protein|dynamin family member proline-rich carboxyl-terminal domain less|dynamin-like protein 4|dynamin-like protein IV|dynamin-related protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DNM1L, check out the DNM1L Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DNM1L: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Dynamin-1-like protein DNM1L Antibody (A00556)
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