This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Dynamin-1-like protein Antibodies
AND DNM1L ELISA kits, Dynamin-1-like protein Proteins
Many biological assays use antibodies to detect Dynamin-1-like protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dynamin-1-like protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dynamin-1-like protein antibodies...
Previous: CCN4
Next: ABCC9
DNM1L Infographic by Boster Bio
All DNM1L Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00556S637-1
100ul
Cat # A00556S637-1
100ul
Anti-DRP1/DNM1L Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00556-2
100 μg/vial
Cat # A00556-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M00556-1
100 µl
Cat # M00556-1
100 µl
Dog, Human, Monkey, Mouse, Rat
IHC, WB
$523
Cat # M00556-2
100 µl
Cat # M00556-2
100 µl
DNM1L Overview
Facts about Dynamin-1-like protein.
Dynamin-1-like protein (DNM1L)
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism.
The specific recruiting at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:29899447). While the recruitment from the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation in the receptors and allows DNM1L filaments to float into closed rings that are probably enough to sever a double membrane (PubMed:29899447).
Gene Information
| Human | |
|---|---|
| Gene Name: | DNM1L |
| Uniprot: | O00429 |
| Entrez: | 10059 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
DLP1; DRP1Dnm1p/Vps1p-like protein; DVLPEC 3.6.5.5; Dymple; DYMPLEDYNIV-11; dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; dynamin-1-like protein; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-like protein; Dynamin-related protein 1; FLJ41912; HDYNIV; VPS1
Molecular Weight
Mass (kDA):
81.877 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p11.21 |
| Sequence: | 12; NC_000012.12 (32679200..32745650) |
Tissue Specificity
Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons.
Subcellular Localizations
Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Mainly cytosolic. Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Colocalized with MARCHF5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Ass
Diseases
- Neurodegenerative Disorders
- Parkinson Disease
- Alzheimer's Disease
- Nerve Degeneration
- Malignant Neoplasms
- Huntington Disease
- Optic Atrophy
- Atrophy
- Mitochondrial Diseases
- Neuroblastoma
- Diabetes Mellitus
- Ischemia
- Stenosis
Interacting Proteins
- ESR1
- LRRK2
- MIEF1
- MIEF2
- SAMM50
- SCRIB
Pathways
- Mitochondrial Fission
- Cell Death
- Pathogenesis
- Mitochondrial Fusion
- Transport
- Rna Interference
- Localization
- Autophagy
- Mitochondrial Translocation
- Mitochondrial Depolarization
- Mitosis
- Mitochondrial Outer Membrane Permeabilization
- Regulation Of Mitochondrial Fission
PTMs
- Phosphorylation
- Dephosphorylation
- Ubiquitination
- Sumoylation
Research Areas
- Apoptosis
- Cell Biology
- Mitochondrial Fusion Proteins
- Mitochondrial-Mediated Pathway
- Neurodegeneration
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNM1L
bosterbio.com/bosterbio-gene-info-cards/DNM1L
References
PMID: 9348079 by Shin H.-W., et al. Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p.
PMID: 9731200 by Hong Y.-R., et al. Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.
1 Publications of Boster Dynamin-1-like protein Antibodies & ELISA Kits
- PubMed ID: 10.1007/s00795-021-00306-5, Nicorandil, an ATP-sensitive potassium channel activation, attenuates myocardial...
*More publications can be found for each product on its corresponding product page