Anti-DKK2 Antibody

Product Name

Anti-DKK2 Antibody

View all Dkk-2 Antibodies

SKU/Catalog Number

M06431

Size

50 µl

Description

Boster Bio Anti-DKK2 Antibody (Catalog # M06431). Tested in WB application(s). This antibody reacts with Human, Mouse.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-DKK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06431)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Monoclonal

Clone Number

1833CT856.7.20

Isotype

IgG1,k

Immunogen

This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M06431 is reactive to DKK2 in Human, Mouse

Applications

M06431 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

28447 Da

Background of Dkk-2

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:2000

Validation Images & Assay Conditions

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All lanes : Anti-DKK2 Antibody at 1:2000 dilution
Lane 1: Human brain lysate
Lane 2: Mouse heart lysate
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 28 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Gene/Protein Information For DKK2 (Source: Uniprot.org, NCBI)

Alternative Names

dickkopf (Xenopus laevis) homolog 2; dickkopf 2; dickkopf homolog 2 (Xenopus laevis); dickkopf related protein-2; dickkopf-2; dickkopf-related protein 2; Dkk2; Dkk-2; hDkk-2 DKK2 DKK-2 dickkopf WNT signaling pathway inhibitor 2 dickkopf-related protein 2|dickkopf 2 homolog|dickkopf homolog 2|dickkopf-2|hDkk-2

For more info on DKK2, check out the DKK2 Infographic

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In this infographic, you will see the following information for DKK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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