Anti-CRIM2 KCP Antibody

Product Name

Anti-CRIM2 KCP Antibody

View all Kcp Antibodies

SKU/Catalog Number

A11951

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-CRIM2 KCP Antibody (Catalog # A11951). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

CRIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-CRIM2 KCP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11951)

Host

Rabbit

Contents

CRIM2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

CRIM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2. The immunogen is located within amino acids 1320 - 1370 of CRIM2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least two isoforms of CRIM2 are known to exist; this antibody will only detect the larger isoform. CRIM2 antibody is predicted to not cross-react with CRIM1.

Reactive Species

A11951 is reactive to KCP in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

166935 MW

Background of Kcp

CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-β1, suppressing activin- and TGF-β1-dependent transcription.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A11951 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For KCP (Source: Uniprot.org, NCBI)

Alternative Names

KCP1, CRIM2, NET67, KCP1, Cysteine-rich BMP regulator 2, CRIM-2 Kcp|AW060220, CRIM-2, Cri, Crim2, Gm793, KC, KCP-1|kielin/chordin-like protein|kielin/chordin-like protein|cysteine rich BMP regulator 2 (chordin like)|cysteine-rich BMP regulator 2|cysteine-rich motor neuron 2 protein|kielin/chordin-like protein 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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