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Product Info Summary
| SKU: | A00205 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | IF, IHC, WB |
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Product info
Product Name
Anti-CREB-BP Antibody
SKU/Catalog Number
A00205
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-CREB-BP Antibody (Catalog # A00205). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CREB-BP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00205)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CREB-BP.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A00205 is reactive to CREBBP in Human
Reconstitution
Calculated molecular weight
265351 MW
Background of CBP/KAT3A
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 - 5340.
Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 - 55681.
Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051.
Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00205 is guaranteed for IF, IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Validation Images & Assay Conditions
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB-BP antibody A00205.
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Western blot analysis of extracts from HeLa cells, treated with insulin (0.01U/ml, 15mins), using CREB-BP antibody A00205.
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Immunofluorescence analysis of A549 cells, using CREB-BP antibody A00205.
Protein Target Info & Infographic
Gene/Protein Information For CREBBP (Source: Uniprot.org, NCBI)
Gene Name
CREBBP
Full Name
CREB-binding protein
Weight
265351 MW
Alternative Names
CREB-binding protein;2.3.1.48 ;CREBBP;CBP; CREBBP CBP, KAT3A, MKHK1, RSTS, RSTS1 CREB binding protein CREB-binding protein|histone lysine acetyltransferase CREBBP|protein-lysine acetyltransferase CREBBP
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CREBBP, check out the CREBBP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CREBBP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CREB-BP Antibody (A00205)
Hello CJ!
A00205 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Role of CREB in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-CREB-BP Antibody
Question
What is the amino acid sequence of the epitope for A00205?
Verified customer
Asked: 2019-09-14
Answer
The immunogen sequence for the Anti-CREB-BP Antibody (A00205) is VGDTTGDTLEKFVEGL. (uniprot: Q92793)
Boster Scientific Support
Answered: 2019-09-17
