Anti-CPN cat CPN1 Antibody

Product Name

Anti-CPN cat CPN1 Antibody

View all CPN1 Antibodies

SKU/Catalog Number

A05704

Size

100μl

Form

Liquid

Description

Boster Bio Anti-CPN cat CPN1 Antibody catalog # A05704. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CPN cat CPN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05704)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from the C-terminal region of human CPN cat. at AA rangle: 380-460

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A05704 is reactive to CPN1 in Human

Applications

A05704 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

52286 MW

Background of CPN1

ROC2 also known as RING-box protein 2, Rbx2, RING finger protein 7, Regulator of cullins 2, CKII beta-binding protein 1, and CKBBP1, is a probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC2 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. ROC2 may play a role in protecting cells from apoptosis induced by redox agents. ROC2 has a cytoplasmic and nuclear localization and is expressed in heart, liver, skeletal muscle and pancreas tissues, and at very low levels in brain, placenta and lung. 1,10-phenanthroline induces ROC2 expression. The RING-type zinc finger domain is essential for ubiquitin ligase activity. Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

Click image to see more details

Western Blot (WB) analysis of HeLa cells using CPN cat Polyclonal antibody.

Click image to see more details

Western Blot (WB) analysis of specific cells using CPN cat Polyclonal antibody.

Gene/Protein Information For CPN1 (Source: Uniprot.org, NCBI)

Alternative Names

ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1; carboxypeptidase N, polypeptide 1, 50kD; CPNcarboxypeptidase N catalytic chain; EC 3.4.17; EC 3.4.17.3; FLJ40792; kininase I; kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; SCPNcarboxypeptidase N catalytic subunit; Serum carboxypeptidase N CPN1 CPN, SCPN carboxypeptidase N subunit 1 carboxypeptidase N catalytic chain|anaphylatoxin inactivator|arginine carboxypeptidase|carboxypeptidase K|carboxypeptidase N catalytic subunit|carboxypeptidase N polypeptide 1 50 kD|carboxypeptidase N small subunit|carboxypeptidase N, polypeptide 1|kininase I|kininase-1|lysine carboxypeptidase|plasma carboxypeptidase B|serum carboxypeptidase N

For more info on CPN1, check out the CPN1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CPN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Take me to the CPN1 Infographic

Here are featured tools and databases that you might find useful.

• Boster's Pathways Library
• Protein Databases
• Bioscience Research Protocol Resources
• Data Processing & Analysis Software
• Photo Editing Software
• Scientific Literature Resources
• Research Paper Management Tools
• Molecular Biology Software
• Primer Design Tools
• Bioinformatics Tools
• Phylogenetic Tree Analysis