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Product Info Summary
| SKU: | A08887-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-CIP75 UBQLN4 Antibody
View all UBQLN4/CIP75 Antibodies
SKU/Catalog Number
A08887-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CIP75 UBQLN4 Antibody (Catalog # A08887-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CIP75 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CIP75 UBQLN4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08887-1)
Host
Rabbit
Contents
CIP75 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CIP75 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CIP75. The immunogen is located within the first 50 amino acids of CIP75.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
CUEDC2 antibody will not cross-react with CUEDC1.
Reactive Species
A08887-1 is reactive to UBQLN4 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
63853 MW
Background of UBQLN4/CIP75
The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08887-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CIP75 antibody can be used for detection of CIP75 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CIP75 in 3T3 cell lysate with CIP75 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of CIP75 in mouse kidney tissue with CIP75 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For UBQLN4 (Source: Uniprot.org, NCBI)
Gene Name
UBQLN4
Full Name
Ubiquilin-4
Weight
63853 MW
Alternative Names
A1U, A1Up, UBIN, CIP75, C1orf6, Ubiquilin-4, Ataxin-1 interacting ubiquitin-like protein UBQLN4 A1U, A1Up, C1orf6, CIP75, UBIN ubiquilin 4 ubiquilin-4|ataxin-1 interacting ubiquitin-like protein|ataxin-1 ubiquitin-like interacting protein|ataxin-1 ubiquitin-like-interacting protein A1U|connexin43-interacting protein of 75 kDa
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on UBQLN4, check out the UBQLN4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for UBQLN4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CIP75 UBQLN4 Antibody (A08887-1)
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