Anti-CEACAM1 (human) Monoclonal Antibody (GM8G5)

Product Name

Anti-CEACAM1 (human) Monoclonal Antibody (GM8G5)

View all CEACAM1 Antibodies

SKU/Catalog Number

M00923-1

Size

100µg

Form

Liquid. In PBS, pH 7.2. Contains no preservatives.

Description

Boster Bio Anti-CEACAM1 (human) Monoclonal Antibody (GM8G5) catalog # M00923-1. Tested in Flow Cytometry, IHC applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CEACAM1 (human) Monoclonal Antibody (GM8G5) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00923-1)

Host

Mouse

Contents

Liquid. In PBS, pH 7.2. Contains no preservatives.

Clonality

Monoclonal

Clone Number

GM8G5

Isotype

IgM, kappa

Immunogen

Vector containing the cDNA of human CEACAM1 A2 domain.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with primate, avian or amphibian GR.

Reactive Species

M00923-1 is reactive to CEACAM1 in Human

Reconstitution

Reconstitute with distilled water.

Observed Molecular Weight

68 kDa

Calculated molecular weight

14177 MW

Background of CEACAM1

Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). It is useful for study on GPI-anchored proteins, PNH and CD59 functions.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M00923-1 is guaranteed for Flow Cytometry, IHC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Optimal conditions must be determined individually for each application.

Validation Images & Assay Conditions

Gene/Protein Information For CEACAM1 (Source: Uniprot.org, NCBI)

Alternative Names

CD59 glycoprotein;1F5 antigen;20 kDa homologous restriction factor;HRF-20;HRF20;MAC-inhibitory protein;MAC-IP;MEM43 antigen;Membrane attack complex inhibition factor;MACIF;Membrane inhibitor of reactive lysis;MIRL;Protectin;CD59;CD59;MIC11, MIN1, MIN2, MIN3, MSK21; CEACAM1 BGP, BGP1, BGPI CEA cell adhesion molecule 1 carcinoembryonic -related cell adhesion molecule 1|CD66a | CD66|carcinoembryonic related cell adhesion molecule 1|carcinoembryonic -related cell adhesion molecule 1 (biliary glycoprotein)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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