Product Info Summary
SKU: | A09177-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | ELISA, IHC |
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Product info
Product Name
Anti-CDK5 Activator-binding C42 CDK5RAP1 Antibody
SKU/Catalog Number
A09177-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-CDK5 Activator-binding C42 CDK5RAP1 Antibody catalog # A09177-1. Tested in ELISA, IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CDK5 Activator-binding C42 CDK5RAP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09177-1)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CDK5 Activator-binding C42
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09177-1 is reactive to CDK5RAP1 in Human
Applications
A09177-1 is guaranteed for ELISA, IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
67689 MW
Background of CDK5RAP1
Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity.
Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).
Ota T., Nat. Genet. 36:40-45(2004).
Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC 1:100-1:300
ELISA 1:20000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of CDK5RAP1 using Anti-CDK5 Activator-binding C42 CDK5RAP1 Antibody (A09177-1).
Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°CProtein Target Info & Infographic
Gene/Protein Information For CDK5RAP1 (Source: Uniprot.org, NCBI)
Gene Name
CDK5RAP1
Full Name
CDK5 regulatory subunit-associated protein 1
Weight
67689 MW
Superfamily
methylthiotransferase family
Alternative Names
C20orf34; C42; CDK5 activator-binding protein C42; CDK5 regulatory subunit associated protein 1; CDK5 regulatory subunit-associated protein 1; CDK5RAP1.3; CDK5RAP1.4; CGI-05; chromosome 20 open reading frame 34; HSPC167 CDK5RAP1 C20orf34, C42, CGI-05, HSPC167 CDK5 regulatory subunit associated protein 1 mitochondrial tRNA methylthiotransferase CDK5RAP1|CDK5 activator-binding protein C42|mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase|mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CDK5RAP1, check out the CDK5RAP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CDK5RAP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CDK5 Activator-binding C42 CDK5RAP1 Antibody (A09177-1)
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