Anti-CBLN1/Precerebellin Antibody

Product Name

Anti-CBLN1/Precerebellin Antibody

View all CBLN1 Antibodies

SKU/Catalog Number

A09176

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-CBLN1/Precerebellin Antibody (Catalog # A09176). Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CBLN1/Precerebellin Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09176)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human CBLN1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A09176 is reactive to CBLN1 in Human

Reconstitution

Calculated molecular weight

21097 MW

Background of CBLN1

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity.

Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).
Ota T., Nat. Genet. 36:40-45(2004).
Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A09176 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For CBLN1 (Source: Uniprot.org, NCBI)

Alternative Names

Cerebellin-1;Precerebellin;Cerebellin;CER;[des-Ser1]-cerebellin;CBLN1; CBLN1 cerebellin 1 precursor cerebellin-1|precerebellin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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