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Product Info Summary
| SKU: | A09778 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Calpain-6 CAPN6 Antibody
SKU/Catalog Number
A09778
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Calpain-6 CAPN6 Antibody (Catalog # A09778). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CAPN6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Calpain-6 CAPN6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09778)
Host
Rabbit
Contents
CAPN6 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CAPN6 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human CAPN6. The immunogen is located within the last 50 amino acids of CAPN6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SLC36A2 antibody is human specific. SLC36A2 is predicted to not cross-react with other members of the SLC36 protein family.
Reactive Species
A09778 is reactive to CAPN6 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
74576 MW
Background of Calpain 6
Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09778 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CAPN6 antibody can be used for the detection of StrepII by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CAPN6 in rat lung tissue lysate with CAPN6 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of CAPN6 in human lung tissue with CAPN6 antibody at 2.5 μg/mL.
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Immunofluorescence of CAPN6 in Human Lung cells with CAPN6 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CAPN6 (Source: Uniprot.org, NCBI)
Gene Name
CAPN6
Full Name
Calpain-6
Weight
74576 MW
Superfamily
peptidase C2 family
Alternative Names
CANPX, CAPNX, CalpM, DJ914P14.1, CALPM, CANPX, Calpain-6, Calpain-like protease X-linked CAPN6 CANPX, CAPNX, CalpM, DJ914P14.1 calpain 6 calpain-6|calpain-like protease X-linked|calpamodulin
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CAPN6, check out the CAPN6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CAPN6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Calpain-6 CAPN6 Antibody (A09778)
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