Anti-C-C chemokine receptor type 8 CCR8 Antibody

Product Name

Anti-C-C chemokine receptor type 8 CCR8 Antibody

View all CCR8 Antibodies

SKU/Catalog Number

A03518

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-C-C chemokine receptor type 8 CCR8 Antibody (Catalog # A03518). Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

CCR8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-C-C chemokine receptor type 8 CCR8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03518)

Host

Rabbit

Contents

CCR8 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

CCR8 antibody was raised against a 19 amino acid peptide near the center of human CCR8. The immunogen is located within amino acids 170 - 220 of CCR8.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

LRRC8A antibody is human, mouse and rat reactive.

Reactive Species

A03518 is reactive to CCR8 in Human

Applications

A03518 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

24687 MW

Background of CCR8

CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309. CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CCR8 antibody can be used for detection of CCR8 by Western blot 0.5 μg/mL. An approximately 50 kDa band can be detected.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of CCR8 in human spleen lysate with CCR8 antibody at 1:500 dilution.

Gene/Protein Information For CCR8 (Source: Uniprot.org, NCBI)

Alternative Names

CC chemokine receptor 8; C-C CKR-8; CC-chemokine receptor chemr1; CC-CKR-8; CCR8; CCR-8; CD198; CDw198 antigen; CDw198; chemokine (C-C motif) receptor 8; chemokine (C-C) receptor 8; chemokine (C-C) receptor-like 2; Chemokine receptor-like 1; ChemR1; CKRL1; CKR-L1; CKRL1MGC129966; CMKBR8MGC129973; CMKBRL2C-C chemokine receptor type 8; CY6; GPRCL1; GPRCY6; GPR-CY6; TER-1; TER1CC chemokine receptor CHEMR1 CCR8 CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1 C-C motif chemokine receptor 8 C-C chemokine receptor type 8|CC chemokine receptor 8|CC chemokine receptor CHEMR1|CC-chemokine receptor chemr1|chemokine (C-C motif) receptor 8|chemokine (C-C) receptor 8|chemokine (C-C) receptor-like 2|chemokine receptor-like 1

For more info on CCR8, check out the CCR8 Infographic

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In this infographic, you will see the following information for CCR8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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