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BRCA1 Antibodies
AND BRCA1 ELISA kits, BRCA1 Proteins
Many biological assays use antibodies to detect BRCA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRCA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRCA1 antibodies...
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BRCA1 Infographic by Boster Bio
All BRCA1 Products
Product
Figures
Specificity
Applications
Price
Anti-BRCA1 Antibody Picoband®
3 Citations 20 Q&As
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9015
100 μg/vial
Cat # PB9015
100 μg/vial
Anti-BRCA1 Antibody Picoband®
1 Citations 15 Q&As
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # A00005
100 μg/vial
Cat # A00005
100 μg/vial
Anti-BRCA1 (Breast Marker) Monoclonal Antibody
1 Citations 3 Q&As
Human
IHC
$486
Cat # M00005
100ug/vial
Cat # M00005
100ug/vial
Human
ELISA
$480
Cat # EKC1066
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1066
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2607
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2607
1 kit, containing two 96-well plates and all necessary reagents
BRCA1 Overview
Facts about Breast cancer type 1 susceptibility protein.
Breast cancer type 1 susceptibility protein (BRCA1)
It is unclear whether it also mediates the formation of different kinds of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function.
The BRCA1-BARD1 heterodimer coordinates a wide range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Required for normal cell cycle progression from G2 into mitosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | BRCA1 |
| Uniprot: | P38398 |
| Entrez: | 672 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BRCA1; BRCAI; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; EC 6.3.2; EC 6.3.2.-; IRIS; PNCA4; PSCP; subunit 1
Molecular Weight
Mass (kDA):
207.721 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (43044295..43125364, complement) |
Tissue Specificity
Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
Subcellular Localizations
Nucleus. Chromosome. Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719).; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm.
Diseases
- Malignant Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Carcinoma
- Brca1 Gene Mutation
- Brca2 Gene Mutation
- Cell Transformation, Neoplastic
- Hereditary Breast Carcinoma
- Carcinogenesis
- Epithelial Ovarian Cancer
Interacting Proteins
- ABRAXAS1
- ACACA
- BAP1
- BARD1
- BCL2
- BRAP
- BRAT1
- BRIP1
- CCND1
- CCNE1
Pathways
- Dna Repair
- Cell Cycle
- Localization
- Methylation
- Pathogenesis
- Cell Proliferation
- Cell Death
- Dna Replication
- Cell Growth
- Hypersensitivity
- Cell Cycle Arrest
- Dna Methylation
- S Phase
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Cleavage
- Acetylation
- Dephosphorylation
- Demethylation
- Sumoylation
- Deacetylation
Research Areas
- Apoptosis
- Breast Cancer
- Cancer
- Cell Biology
- Chromatin Research
- DNA Double Strand Break Repair
- DNA Repair
- Homologous Recombination
- Tumor Suppressors
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRCA1
bosterbio.com/bosterbio-gene-info-cards/BRCA1
References
PMID: 7545954 by Miki Y., et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
PMID: 8938427 by Smith T.M., et al. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.
3 Publications of Boster BRCA1 Antibodies & ELISA Kits
- PubMed ID: 10.3390/nu11112559, Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast C...
- PubMed ID: 28771232, Liu JC, Lai FN, Li L, Sun XF,, Cheng SF, Ge W, Wang YF, Li L, Zhang XF, De Felic...
- PubMed ID: 23276146, Zhang Q, Zhang Q, Cong H, Zhang X. Diagn Pathol. 2012 Dec 31;7:181. Doi: 10.1186...
*More publications can be found for each product on its corresponding product page