Product Info Summary
SKU: | A09207 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-ATP2C2 Antibody
SKU/Catalog Number
A09207
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ATP2C2 Antibody (Catalog # A09207). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
ATP2C2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ATP2C2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09207)
Host
Rabbit
Contents
ATP2C2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ATP2C2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP2C2. The immunogen is located within the first 50 amino acids of ATP2C2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1
Reactive Species
A09207 is reactive to ATP2C2 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
103169 MW
Background of ATP2C2
ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09207 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ATP2C2 antibody can be used for detection of ATP2C2 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Click image to see more details
Immunofluorescence of ATP2C2 in 3T3 cells with ATP2C2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ATP2C2 (Source: Uniprot.org, NCBI)
Gene Name
ATP2C2
Full Name
Calcium-transporting ATPase type 2C member 2
Weight
103169 MW
Superfamily
cation transport ATPase (P-type) (TC 3.A.3) family
Alternative Names
SPCA2, KIAA0703, SPCA2, Calcium-transporting ATPase type 2C member 2, ATPase 2C2 ATP2C2 SPCA2 ATPase secretory pathway Ca2+ transporting 2 calcium-transporting ATPase type 2C member 2|ATPase 2C2|ATPase, Ca++ transporting, type 2C, member 2|secretory pathway Ca(2+)-ATPase 2|secretory pathway calcium ATPase 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ATP2C2, check out the ATP2C2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ATP2C2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ATP2C2 Antibody (A09207)
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