ASIC3 Antibodies

AND ASIC3 ELISA kits, ASIC3 Proteins

Many biological assays use antibodies to detect ASIC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ASIC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ASIC3 antibodies...

We validate the specificity of these antibodies to ASIC3 by testing them on tissues known to express ASIC3 positively and negatively. Browse below to find the ASIC3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ASIC3 Infographic by Boster Bio

All ASIC3 Products

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Specificity

Applications

Price

Anti-Acid-sensing ion channel 3 ASIC3 Antibody Picoband®

2 Citations 6 Q&As

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # PA1938
100 μg/vial

ASIC3 (NM_004769) Human Over-expression Lysate

Human

$960
Cat # LS009311
100 µg

ASIC3 Overview

Facts about Acid-sensing ion channel 3.

ASIC3 3D structure. Source: alphafold

Acid-sensing ion channel 3 (ASIC3)

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase.

In sensory neurons is suggested to mediate the pain induced by acidosis occurring in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia.

Gene Information

Human
Gene Name:	ASIC3
Uniprot:	Q9UHC3
Entrez:	9311

Family

Belongs to:

amiloride-sensitive sodium channel (TC 1.A.6) family

Alternative Names

Acid-sensing ion channel 3; amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; ASIC3hTNaC1; DRASIC; hASIC3; modulatory subunit of ASIC2a; Neuronal amiloride-sensitive cation channel 3; proton-gated cation channel subunit; SLNAC1; Testis sodium channel 1; TNaC1

Molecular Weight

Mass (kDA):
58.905 kDA

Genomic Context


Human

Location:	7q36.1
Sequence:	7; NC_000007.14 (151048292..151052756)

Tissue Specificity

Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity).

Diseases

Pain
Acidosis
Inflammation
Nervousness
Hyperalgesia
Ischemia
Hyperalgesias, Mechanical
Myocardial Ischemia
Chronic Pain
Arthritis
Myalgia
Angina Pectoris

Myositis
Neoplasms
Visceral Pain
Myocardial Infarction
Nerve Degeneration
Thermal Hyperalgesia

Pathways

Localization
Sensitization
Hypersensitivity
Reflex
Synaptic Transmission
Membrane Depolarization
Pathogenesis
Transport
Sensory Perception
Response To Acid
Secretion
Osteoclast Differentiation
Cell Migration

Muscle Cell Migration
Brain Development
Aging
Muscle Contraction
Taste Perception
Transepithelial Transport
Chemotaxis

PTMs

Phosphorylation

Methylation

Palmitoylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASIC3

References

PMID: 9571199 by Ishibashi K., et al. Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis.

PMID: 9744806 by de Weille J.R., et al. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel.

2 Publications of Boster ASIC3 Antibodies & ELISA Kits

PubMed ID: 10.1152/ajpregu.00148.2019, Effect of knockout of the ASIC3 on cardiovascular reflexes arising from hindlimb...
PubMed ID: 29237731, Schuhmacher LN, Callejo G, Srivats S, Smith ESJ. J Biol Chem. 2018 Feb 2;293(5):...

*More publications can be found for each product on its corresponding product page