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Product Info Summary
| SKU: | A01682 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Antileukoproteinase SLPI Antibody
SKU/Catalog Number
A01682
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Antileukoproteinase SLPI Antibody (Catalog # A01682). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.
Storage & Handling
SLPI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Antileukoproteinase SLPI Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01682)
Host
Rabbit
Contents
SLPI Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SLPI antibody was raised against a 17 amino acid synthetic peptide from near the center of human SLPI. The immunogen is located within amino acids 60 - 110 of SLPI.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SREBF2 antibody is human and mouse reactive. At least three isoforms of SREBF2 are known to exist. SREBF2 antibody is predicted not to cross-react with SREBF1.
Reactive Species
A01682 is reactive to SLPI in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
14326 MW
Background of SLPI
Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-κB activation by inhibiting IκB degradation in the cytoplasm and competing for NF-κB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01682 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SLPI antibody can be used for detection of SLPI by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SLPI in Daudi cell lysate with SLPI antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of SLPI in mouse lung tissue with SLPI antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SLPI (Source: Uniprot.org, NCBI)
Gene Name
SLPI
Full Name
Antileukoproteinase
Weight
14326 MW
Alternative Names
ALP, MPI, ALK1, BLPI, HUSI, WAP4, WFDC4, HUSI-I, Antileukoproteinase, ALP SLPI ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4 secretory leukocyte peptidase inhibitor antileukoproteinase|HUSI-1|WAP four-disulfide core domain protein 4|mucus proteinase inhibitor|protease inhibitor WAP4|secretory leukocyte protease inhibitor (antileukoproteinase)|seminal proteinase inhibitor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SLPI, check out the SLPI Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SLPI: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Antileukoproteinase SLPI Antibody (A01682)
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