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Product Info Summary
| SKU: | A06684-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Anosmin ANOS1 Antibody
SKU/Catalog Number
A06684-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Anosmin ANOS1 Antibody (Catalog # A06684-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
Anosmin antibody can be stored at 4 °C, stable for one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Anosmin ANOS1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06684-1)
Host
Rabbit
Contents
Anosmin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Anosmin antibody was raised against an 18 amino acid synthetic peptide near the center of human Anosmin. The immunogen is located within amino acids 430 - 480 of Anosmin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
VTI1a antibody is human, mouse and rat reactive. At least two isoforms of VTI1a are known to exist; this antibody will detect both isoforms. VTI1a antibody is predicted to not cross-react with VTI1b.
Reactive Species
A06684-1 is reactive to ANOS1 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
76112 MW
Background of KAL1
Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06684-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Anosmin antibody can be used for detection of Anosmin by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Positive Control
Validation Images & Assay Conditions
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Western blot analysis of Anosmin in MCF7 cell lysate with Anosmin antibody at 1 μg/mL.
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Immunocytochemistry of Anosmin in MCF7 cells with Anosmin antibody at 5 μg/mL.
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Immunofluorescence of Anosmin in MCF7 cells with Anosmin antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ANOS1 (Source: Uniprot.org, NCBI)
Gene Name
ANOS1
Full Name
Anosmin-1
Weight
76112 MW
Alternative Names
Adhesion molecule-like X-linked; ADMLXHHA; anosmin-1; KAL; KALIG1; KALIG-1; Kallmann syndrome 1 sequence; Kallmann syndrome interval gene 1; Kallmann syndrome protein; Kallmann syndrome-1 sequence (anosmin-1); KMS ANOS1 ADMLX, HH1, HHA, KAL, KAL1, KALIG-1, KMS, WFDC19 anosmin 1 anosmin-1|Kallmann syndrome interval gene 1|Kallmann syndrome-1 sequence (anosmin-1)|WAP four-disulfide core domain 19|adhesion molecule-like X-linked|kallmann syndrome protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ANOS1, check out the ANOS1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ANOS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Anosmin ANOS1 Antibody (A06684-1)
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