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Abcg5 Antibodies
AND Abcg5 ELISA kits, Abcg5 Proteins
Many biological assays use antibodies to detect Abcg5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Abcg5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Abcg5 antibodies...
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Abcg5 Overview
Facts about ATP-binding cassette sub-family G member 5.
ATP-binding cassette sub-family G member 5 (Abcg5)
ABCG5 and ABCG8 form an obligate heterodimer which mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an important role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion from the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:19846887, PubMed:25378657).
Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG8 has ATPase activity (PubMed:16352607, PubMed:16867993).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Abcg5 |
| Uniprot: | Q99PE8 |
| Entrez: | 27409 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; ATP-binding cassette, subfamily G, member 5; sterolin 1; sterolin-1; STSL
Molecular Weight
Mass (kDA):
73.244 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17 E4|17 55.02 cM |
| Sequence: | 17; |
Tissue Specificity
Detected in liver and jejunum (PubMed:12444248, PubMed:15040800, PubMed:18402465, PubMed:25378657). Detected on enterocyte villi (at protein level) (PubMed:15040800). Expressed in jejunum, ileum and, at lower level, in the liver (PubMed:11138003, PubMed:11907139, PubMed:11099417, PubMed:12444248, PubMed:25378657).
Diseases
- Sitosterolemia
- Hypercholesterolemia
- Atherosclerosis
- Cholecystolithiasis
- Cardiovascular Diseases
- Insulin Resistance
- Malignant Neoplasms
- Inflammation
- Hyperlipidemia
- Xanthoma
- Heart Diseases
- Coronary Heart Disease
Pathways
- Transport
- Secretion
- Excretion
- Cholesterol Transport
- Intestinal Cholesterol Absorption
- Cholesterol Homeostasis
- Intestinal Absorption
- Reverse Cholesterol Transport
- Cholesterol Efflux
- Gallstone Formation
- Sterol Transport
- Lipid Transport
- Localization
PTMs
- Phosphorylation
- Oxidation
- Cleavage
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Abcg5
bosterbio.com/bosterbio-gene-info-cards/Abcg5
References
PMID: 11138003 by Lee M.-H., et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.
PMID: 11907139 by Lu K., et al. Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8.
1 Publications of Boster Abcg5 Antibodies & ELISA Kits
- PubMed ID: 31054325, Li R,Liu Y,Shi J,Yu Y,Lu H,Yu L,Liu Y,Zhang F.Diosgenin regulates cholesterol me...
*More publications can be found for each product on its corresponding product page