ABCC11 Antibodies

AND ABCC11 ELISA kits, ABCC11 Proteins

Many biological assays use antibodies to detect ABCC11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC11 antibodies...

We validate the specificity of these antibodies to ABCC11 by testing them on tissues known to express ABCC11 positively and negatively. Browse below to find the ABCC11 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABCC11 Infographic by Boster Bio

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Anti-ABCC11 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A04931
100ul

ABCC11 Overview

Facts about ATP-binding cassette sub-family C member 11.

ABCC11 3D structure. Source: alphafold

ATP-binding cassette sub-family C member 11 (ABCC11)

Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867).

Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, for example, glutathione S- conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D- glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836).

Gene Information

Human
Gene Name:	ABCC11
Uniprot:	Q96J66
Entrez:	85320

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ATP-binding cassette protein C11; ATP-binding cassette transporter MRP8; ATP-binding cassette transporter sub-family C member 11; ATP-binding cassette, sub-family C (CFTR/MRP), member 11; EWWD; MRP8ATP-binding cassette sub-family C member 11; Multidrug resistance-associated protein 8; multi-resistance protein 8; WW

Molecular Weight

Mass (kDA):
154.301 kDA

Genomic Context


Human

Location:	16q12.1
Sequence:	16; NC_000016.10 (48164842..48249973, complement)

Tissue Specificity

Expressed in ceruminous apocrine gland (at protein level) (PubMed:19383836, PubMed:19710689). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Vacuole membrane. Cytoplasmic vesicle membrane.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Carcinoma
Inflammation
Leukemia
Bromhidrosis
Cystic Fibrosis
Leukemia, Myelocytic, Acute
Fibrosis
Myeloid Leukemia
Sweat Gland Diseases

Arthritis
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Paroxysmal Nonkinesigenic Dyskinesia
Arthritis, Juvenile Rheumatoid
Adenocarcinoma
Malignant Paraganglionic Neoplasm

Pathways

Transport
Drug Resistance
Secretion
Glycosylation
Localization
Pathogenesis
Excretion
Gene Silencing
Programmed Cell Death
Immune Response
Neurogenesis
Regulation Of Gene Expression
Inflammatory Response

Root Morphogenesis
Glucose Homeostasis
Tooth Eruption
Phagocytosis
Drug Transport
Drug Export
Wound Healing

PTMs

Phosphorylation

Glycosylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC11

References

PMID: 11483364 by Tammur J., et al. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.

PMID: 11688999 by Yabuuchi H., et al. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.