ABCB4 Antibodies

AND ABCB4 ELISA kits, ABCB4 Proteins

Many biological assays use antibodies to detect ABCB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCB4 antibodies...

We validate the specificity of these antibodies to ABCB4 by testing them on tissues known to express ABCB4 positively and negatively. Browse below to find the ABCB4 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: SLC25A3

ABCB4 Infographic by Boster Bio

All ABCB4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ABCB4 Antibody Picoband®

Human

$370
Cat # PA2090
100 μg/vial

Anti-ABCB4 Antibody Picoband®

7 Q&As

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # PB9275
100 μg/vial

Anti-Zebrafish ABCB4 Antibody

Zebrafish

$470
Cat # DZ01669
200 μl/vial

Anti-ABCB4 Antibody

Human

$299
Cat # M01669
50 µl

Anti-zebrafish Abcb4 Antibody

Zebrafish

$470
Cat # DZ01669-1
200 μl/vial

ABCB4 Overview

Facts about Phosphatidylcholine translocator ABCB4.

ABCB4 3D structure. Source: alphafold

Phosphatidylcholine translocator ABCB4 (ABCB4)

Energy-dependent phospholipid efflux translocator that functions as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates especially phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes.

Translocation of PC creates the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent action of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132).

Gene Information

Human
Gene Name:	ABCB4
Uniprot:	P21439
Entrez:	5244

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ABC21; ABCB4; ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; EC 3.6.3; EC 3.6.3.44; GBD1; MDR2; MDR3; MDR3MDR2/3; multidrug resistance protein 3; multiple drug resistance 3; P glycoprotein 3/multiple drug resistance 3; PFIC-3; P-glycoprotein 3; P-glycoprotein-3/multiple drug resistance-3; PGY3; PGY3GBD1

Molecular Weight

Mass (kDA):
141.523 kDA

Genomic Context


Human

Location:	7q21.12
Sequence:	7; NC_000007.14 (87398988..87476722, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Membrane raft. Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity). Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157). Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199). Localized preferentially in lipid nonraft domains of